Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway

Systemic administration of synthetic small interfering RNAs (siRNAs) effectively silences hepatocyte gene expression in rodents and primates1–3. Whether or not in vivo gene silencing by synthetic siRNA can disrupt the endogenous microRNA (miRNA) pathway remains to be addressed. Here we show that eff...

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Bibliografische gegevens
Hoofdauteurs: John, Matthias, Constien, Rainer, Akinc, Akin, Goldberg, Michael, Moon, Young-Ah, Spranger, Martina, Hadwiger, Philipp, Soutschek, Jürgen, Vornlocher, Hans-Peter, Manoharan, Muthiah, Stoffel, Markus, Langer, Robert, Anderson, Daniel G., Horton, Jay D., Koteliansky, Victor, Bumcrot, David
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2007
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019095/
https://ncbi.nlm.nih.gov/pubmed/17898712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature06179
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