Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway

Systemic administration of synthetic small interfering RNAs (siRNAs) effectively silences hepatocyte gene expression in rodents and primates1–3. Whether or not in vivo gene silencing by synthetic siRNA can disrupt the endogenous microRNA (miRNA) pathway remains to be addressed. Here we show that eff...

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Detalhes bibliográficos
Main Authors: John, Matthias, Constien, Rainer, Akinc, Akin, Goldberg, Michael, Moon, Young-Ah, Spranger, Martina, Hadwiger, Philipp, Soutschek, Jürgen, Vornlocher, Hans-Peter, Manoharan, Muthiah, Stoffel, Markus, Langer, Robert, Anderson, Daniel G., Horton, Jay D., Koteliansky, Victor, Bumcrot, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019095/
https://ncbi.nlm.nih.gov/pubmed/17898712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature06179
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