Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway

Systemic administration of synthetic small interfering RNAs (siRNAs) effectively silences hepatocyte gene expression in rodents and primates1–3. Whether or not in vivo gene silencing by synthetic siRNA can disrupt the endogenous microRNA (miRNA) pathway remains to be addressed. Here we show that eff...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: John, Matthias, Constien, Rainer, Akinc, Akin, Goldberg, Michael, Moon, Young-Ah, Spranger, Martina, Hadwiger, Philipp, Soutschek, Jürgen, Vornlocher, Hans-Peter, Manoharan, Muthiah, Stoffel, Markus, Langer, Robert, Anderson, Daniel G., Horton, Jay D., Koteliansky, Victor, Bumcrot, David
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2007
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019095/
https://ncbi.nlm.nih.gov/pubmed/17898712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature06179
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