Evolution of I-SceI homing endonucleases with increased DNA recognition site specificity

Elucidating how homing endonucleases undergo changes in recognition site specificity will facilitate efforts to engineer proteins for gene therapy applications. I-SceI is a monomeric homing endonuclease that recognizes and cleaves within an 18-base-pair (bp) target. It tolerates limited degeneracy i...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Joshi, Rakesh, Ho, Kwok Ki, Tenney, Kristen, Chen, Jui-Hui, Golden, Barbara L., Gimble, Frederick S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2010
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019082/
https://ncbi.nlm.nih.gov/pubmed/21029741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.10.029
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller