SR-targeted CaMKII inhibition improves SR Ca(2+) handling, but accelerates cardiac remodeling in mice overexpressing CaMKIIδ(C)

Cardiac myocyte overexpression of CaMKIIδ(C) leads to cardiac hypertrophy and heart failure (HF) possibly caused by altered myocyte Ca(2+) handling. A central defect might be the marked CaMKII-induced increase in diastolic sarcoplasmic reticulum (SR) Ca(2+) leak which decreases SR Ca(2+) load and Ca...

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Autori principali: Huke, Sabine, DeSantiago, Jaime, Kaetzel, Marcia A., Mishra, Shikha, Brown, Joan H., Dedman, John R., Bers, Donald M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018844/
https://ncbi.nlm.nih.gov/pubmed/20971119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.10.014
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