RNAi-based screening identifies the Mms22L–Nfkbil2 complex as a novel regulator of DNA replication in human cells

Cullin 4 (Cul4)-based ubiquitin ligases emerged as critical regulators of DNA replication and repair. Over 50 Cul4-specific adaptors (DNA damage-binding 1 (Ddb1)–Cul4-associated factors; DCAFs) have been identified and are thought to assemble functionally distinct Cul4 complexes. Using a live-cell i...

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Main Authors: Piwko, Wojciech, Olma, Michael H, Held, Michael, Bianco, Julien N, Pedrioli, Patrick G A, Hofmann, Kay, Pasero, Philippe, Gerlich, Daniel W, Peter, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018799/
https://ncbi.nlm.nih.gov/pubmed/21113133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.304
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