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Synthetic lethality: General principles, utility and detection using genetic screens in human cells

Synthetic lethality occurs when the simultaneous perturbation of two genes results in cellular or organismal death. Synthetic lethality also occurs between genes and small molecules, and can be used to elucidate the mechanism of action of drugs. This area has recently attracted attention because of...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखक: Nijman, Sebastian M.B.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Elsevier Science B.V 2011
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018572/
https://ncbi.nlm.nih.gov/pubmed/21094158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2010.11.024
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