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The population genetics of synthetic lethals.

Synthetic lethals are variants at different loci that have little or no effect on viability singly but cause lethality in combination. The importance of synthetic lethals and, more generally, of synthetic deleterious loci (SDL) has been controversial. Here, we derive the expected frequencies for SDL...

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Detalhes bibliográficos
Main Authors: Phillips, P C, Johnson, N A
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1460312/
https://ncbi.nlm.nih.gov/pubmed/9725860
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