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Establishing Genetic Interactions by a Synthetic Dosage Lethality Phenotype

We have devised a genetic screen, termed synthetic dosage lethality, in which a cloned ``reference'' gene is inducibly overexpressed in a set of mutant strains carrying potential ``target'' mutations. To test the specificity of the method, two reference genes, CTF13, encoding a c...

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Autors principals: Kroll, E. S., Hyland, K. M., Hieter, P., Li, J. J.
Format: Artigo
Idioma:Inglês
Publicat: 1996
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1207298/
https://ncbi.nlm.nih.gov/pubmed/8722765
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