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Synthetic lethality: General principles, utility and detection using genetic screens in human cells
Synthetic lethality occurs when the simultaneous perturbation of two genes results in cellular or organismal death. Synthetic lethality also occurs between genes and small molecules, and can be used to elucidate the mechanism of action of drugs. This area has recently attracted attention because of...
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| Format: | Artigo |
| Language: | Inglês |
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Elsevier Science B.V
2011
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3018572/ https://ncbi.nlm.nih.gov/pubmed/21094158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2010.11.024 |
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