High- and Low-Affinity Epidermal Growth Factor Receptor-Ligand Interactions Activate Distinct Signaling Pathways

Signaling mediated by the Epidermal Growth Factor Receptor (EGFR) is crucial in normal development, and aberrant EGFR signaling has been implicated in a wide variety of cancers. Here we find that the high- and low-affinity interactions between EGFR and its ligands activate different signaling pathwa...

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Detaylı Bibliyografya
Asıl Yazarlar: Krall, Jordan A., Beyer, Elsa M., MacBeath, Gavin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2011
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018525/
https://ncbi.nlm.nih.gov/pubmed/21264347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015945
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