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Alanine-scanning mutagenesis defines a conserved energetic hotspot in the Ca(V)α(1) AID-Ca(V)β interaction site that is critical for channel modulation
Voltage-gated calcium channels (Ca(V)s) are large, multisubunit complexes that control cellular calcium entry. Ca(V) pore-forming (Ca(V)α(1)) and cytoplasmic (Ca(V)β) subunits associate through a high-affinity interaction between the Ca(V)α(1) α-interaction domain (AID) and Ca(V)β α-binding pocket (...
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Main Authors: | , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2008
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3018278/ https://ncbi.nlm.nih.gov/pubmed/18275819 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2007.11.010 |
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