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Alanine-scanning mutagenesis defines a conserved energetic hotspot in the Ca(V)α(1) AID-Ca(V)β interaction site that is critical for channel modulation

Voltage-gated calcium channels (Ca(V)s) are large, multisubunit complexes that control cellular calcium entry. Ca(V) pore-forming (Ca(V)α(1)) and cytoplasmic (Ca(V)β) subunits associate through a high-affinity interaction between the Ca(V)α(1) α-interaction domain (AID) and Ca(V)β α-binding pocket (...

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Detalhes bibliográficos
Main Authors: Van Petegem, Filip, Duderstadt, Karl E., Clark, Kimberly A., Wang, Michelle, Minor, Daniel L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018278/
https://ncbi.nlm.nih.gov/pubmed/18275819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2007.11.010
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