An antibody-based biomarker discovery method by mass spectrometry sequencing of complementarity determining regions

Autoantibodies are increasingly used as biomarkers in the detection of autoimmune disorders and cancer. Disease specific antibodies are generally detected by their binding to specific antigens. As an alternative approach, we propose to identify specific complementarity determining regions (CDR) of I...

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Bibliographic Details
Main Authors: Dekker, Lennard J. M., Zeneyedpour, Lona, Brouwer, Eric, van Duijn, Martijn M., Sillevis Smitt, Peter A. E., Luider, Theo M.
Format: Artigo
Language:Inglês
Published: Springer-Verlag 2010
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018266/
https://ncbi.nlm.nih.gov/pubmed/21107826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00216-010-4361-9
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