Nonsense-mediated decay targets have multiple sequence-related features that can inhibit translation

Nonsense-mediated mRNA decay (NMD) is a surveillance system that eliminates transcripts with premature termination codons. In this study, we show that mRNAs targeted by NMD are also suppressed at the translational level. The low translational efficiency (TE) is a consequence of multiple features act...

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Detalhes bibliográficos
Main Authors: Zhang, Zhenguo, Zhou, Li, Hu, Landian, Zhu, Yufei, Xu, Heng, Liu, Yang, Chen, Xianfen, Yi, Xianfu, Kong, Xiangyin, Hurst, Laurence D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3018160/
https://ncbi.nlm.nih.gov/pubmed/21179015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/msb.2010.101
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