Genes That Escape X-Inactivation in Humans Have High Intraspecific Variability in Expression, Are Associated with Mental Impairment but Are Not Slow Evolving

In female mammals most X-linked genes are subject to X-inactivation. However, in humans some X-linked genes escape silencing, these escapees being candidates for the phenotypic aberrations seen in polyX karyotypes. These escape genes have been reported to be under stronger purifying selection than o...

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Main Authors: Zhang, Yuchao, Castillo-Morales, Atahualpa, Jiang, Min, Zhu, Yufei, Hu, Landian, Urrutia, Araxi O., Kong, Xiangyin, Hurst, Laurence D.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2013
Assuntos:
Discoveries
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3840307/
https://ncbi.nlm.nih.gov/pubmed/24023392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/mst148
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