Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay

BACKGROUND: Nonsense-mediated decay is a mechanism that degrades mRNAs with a premature termination codon. That some exons have premature termination codons at fixation is paradoxical: why make a transcript if it is only to be destroyed? One model supposes that splicing is inherently noisy and spuri...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Zhang, Zhenguo, Xin, Dedong, Wang, Ping, Zhou, Li, Hu, Landian, Kong, Xiangyin, Hurst, Laurence D
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2697156/
https://ncbi.nlm.nih.gov/pubmed/19442261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-7-23
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker