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Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay
BACKGROUND: Nonsense-mediated decay is a mechanism that degrades mRNAs with a premature termination codon. That some exons have premature termination codons at fixation is paradoxical: why make a transcript if it is only to be destroyed? One model supposes that splicing is inherently noisy and spuri...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2697156/ https://ncbi.nlm.nih.gov/pubmed/19442261 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-7-23 |
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