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Int6 regulates both proteasomal degradation and translation initiation and is critical for proper formation of acini by human mammary epithelium: Dual regulation of protein synthesis and degradation by Int6
INT6/EIF3E has been implicated in breast tumorigenesis, but its functional activities remain poorly defined. We found that repressing INT6 expression induced transformed properties in normal human mammary epithelium (MCF10A); in contrast, Int6 silencing induced apoptosis in HeLa cells. As in yeast,...
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| Główni autorzy: | , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2010
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3017639/ https://ncbi.nlm.nih.gov/pubmed/20890303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.445 |
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