Int6 regulates both proteasomal degradation and translation initiation and is critical for proper formation of acini by human mammary epithelium: Dual regulation of protein synthesis and degradation by Int6

INT6/EIF3E has been implicated in breast tumorigenesis, but its functional activities remain poorly defined. We found that repressing INT6 expression induced transformed properties in normal human mammary epithelium (MCF10A); in contrast, Int6 silencing induced apoptosis in HeLa cells. As in yeast,...

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Main Authors: Suo, Jinfeng, Snider, Sarah J., Mills, Gordon B., Creighton, Chad J., Chen, Albert, Schiff, Rachel, Lloyd, Richard E., Chang, Eric C.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017639/
https://ncbi.nlm.nih.gov/pubmed/20890303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.445
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