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Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1
TopBP1 is a scaffold protein that coordinates activation of the DNA-damage-checkpoint response by coupling binding of the 9-1-1 checkpoint clamp at sites of ssDNA, to activation of the ATR–ATRIP checkpoint kinase complex. We have now determined the crystal structure of the N-terminal region of human...
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| Hoofdauteurs: | , , |
|---|---|
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Oxford University Press
2011
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3017600/ https://ncbi.nlm.nih.gov/pubmed/20724438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq743 |
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