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Natural and engineered nicking endonucleases—from cleavage mechanism to engineering of strand-specificity
Restriction endonucleases (REases) are highly specific DNA scissors that have facilitated the development of modern molecular biology. Intensive studies of double strand (ds) cleavage activity of Type IIP REases, which recognize 4–8 bp palindromic sequences, have revealed a variety of mechanisms of...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3017599/ https://ncbi.nlm.nih.gov/pubmed/20805246 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq742 |
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