Vesicular Stomatitis Virus-induced Immune Suppressor Cells Generate Antagonism Between Intratumoral Oncolytic Virus and Cyclophosphamide

Despite having potent oncolytic activity, in vitro, direct intratumoral injection of oncolytic vesicular stomatitis virus (VSV) into established AE17ova mesothelioma tumors in C57Bl/6 mice had no therapeutic effect. During studies to combine systemic cyclophosphamide (CPA) with VSV to suppress the i...

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Main Authors: Willmon, Candice, Diaz, Rosa M, Wongthida, Phonphimon, Galivo, Feorillo, Kottke, Timothy, Thompson, Jill, Albelda, Steven, Harrington, Kevin, Melcher, Alan, Vile, Richard
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2011
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017451/
https://ncbi.nlm.nih.gov/pubmed/20978474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.224
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