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Systemic Administration of Ribbon-type Decoy Oligodeoxynucleotide Against Nuclear Factor κB and Ets Prevents Abdominal Aortic Aneurysm in Rat Model

Currently, there is no effective clinical treatment to prevent abdominal aortic aneurysm (AAA). To develop a novel therapeutic approach, we modified decoy oligodeoxynucleotide (ODN) against nuclear factor κB (NFκB) and ets, to a ribbon-shaped circular structure without chemical modification, to incr...

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Detalhes bibliográficos
Main Authors: Miyake, Takashi, Aoki, Motokuni, Osako, Mariana K, Shimamura, Munehisa, Nakagami, Hironori, Morishita, Ryuichi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017441/
https://ncbi.nlm.nih.gov/pubmed/20877343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.208
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