Irbesartan improves endothelial dysfunction, abnormal lipid profile, proteinuria and liver dysfunction in Zucker diabetic fatty rats independent of glucose and insulin levels

Treatment with angiotensin type 1 receptor blockers (ARBs) is known to improve renal dysfunction and glucose metabolism in obese diabetic animal models and humans. This study examined the effects of irbesartan, a unique ARB with PPARγ activation, on endothelial dysfunction, renal dysfunction, abnorm...

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Detalhes bibliográficos
Main Authors: SHIMAMURA, MUNEHISA, NAKAGAMI, HIRONORI, SHIMOSATO, TAKASHI, MORITANI, TOSHINORI, NAKAGAMI, FUTOSHI, OSAKO, MARIANA KIOMY, MIYAKE, TAKASHI, KORIYAMA, HIROSHI, SHIMIZU, HIDEO, MORISHITA, RYUICHI
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3440832/
https://ncbi.nlm.nih.gov/pubmed/22977605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm.2011.307
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