Gene Therapy of Canine Leukocyte Adhesion Deficiency Using Lentiviral Vectors With Human CD11b and CD18 Promoters Driving Canine CD18 Expression

To identify cellular promoters in a self-inactivating (SIN) lentiviral vector that might be beneficial in treating children with leukocyte adhesion deficiency type 1 (LAD-1), we tested lentiviral vectors with human CD11 and CD18 leukocyte integrin proximal promoter elements directing expression of c...

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Detalhes bibliográficos
Main Authors: Hunter, Michael J, Tuschong, Laura M, Fowler, Cedar J, Bauer, Thomas R, Burkholder, Tanya H, Hickstein, Dennis D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017439/
https://ncbi.nlm.nih.gov/pubmed/20859258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2010.203
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