Gene Therapy for Canine Leukocyte Adhesion Deficiency with Lentiviral Vectors Using the Murine Stem Cell Virus and Human Phosphoglycerate Kinase Promoters

Children with leukocyte adhesion deficiency type 1 (LAD-1) and dogs with canine LAD (CLAD) develop life-threatening bacterial infections due to mutations in the leukocyte integrin CD18. Here, we compared the human phosphoglycerate kinase (hPGK) promoter to the murine stem cell virus (MSCV) promoter/...

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Detalhes bibliográficos
Main Authors: Hunter, Michael J., Zhao, Huifen, Tuschong, Laura M., Bauer, Thomas R., Burkholder, Tanya H., Persons, Derek A., Hickstein, Dennis D.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2011
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107578/
https://ncbi.nlm.nih.gov/pubmed/21275758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2010.130
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