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Regulation of NK cell responsiveness to achieve self tolerance and maximal responses to diseased target cells

Inhibitory receptors specific for MHC class I molecules govern the capacity of NK cells to attack class I-deficient cells (“missing-self recognition”). These receptors are expressed stochastically, such that the panel of expressed receptors varies between NK cells. This review addresses how the acti...

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Bibliografiske detaljer
Main Authors: Joncker, Nathalie T., Raulet, David H.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017429/
https://ncbi.nlm.nih.gov/pubmed/18759922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-065X.2008.00658.x
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