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NK Cell Responsiveness is Tuned Commensurate with the Number of Inhibitory Receptors for Self MHC Class I: the Rheostat Model
Inhibitory receptors that engage self-MHC class I molecules enable NK cells to detect disease-associated loss of MHC class I on surrounding cells. Previous studies showed that some NK cells lack all receptors for self-MHC class I, yet fail to exhibit autoimmunity because they are generally hyporespo...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2938179/ https://ncbi.nlm.nih.gov/pubmed/19342631 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0803900 |
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