Propylthiouracil blocks extrathyroidal conversion of thyroxine to triiodothyronine and augments thyrotropin secretion in man.

Propylthiouracil (PTU) inhibits peripheral deiodination of thyroxine (T4) and triiodothyronine (T3) and decreases the metabolic effectiveness of T4 in animals. To assess the effect of PTU on extrathyroidal conversion of T4 to T3 in man, 15 studies were performed in athyreotic patients treated with 1...

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Pubblicato in:	J Clin Invest
Autori principali:	Geffner, D L, Azukizawa, M, Hershman, J M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1975
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC301740/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/805160/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI107925
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