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Neurogenin3 inhibits proliferation in endocrine progenitors by inducing Cdkn1a

During organogenesis, the final size of mature cell populations depends on their rates of differentiation and expansion. Because transient expression of Neurogenin3 (Neurog3) in progenitor cells in the developing pancreas initiates their differentiation to mature islet cells, we examined the role of...

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Bibliografske podrobnosti
Main Authors: Miyatsuka, Takeshi, Kosaka, Yasuhiro, Kim, Hail, German, Michael S.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017196/
https://ncbi.nlm.nih.gov/pubmed/21173230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004842108
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