Multi-site Neurogenin3 Phosphorylation Controls Pancreatic Endocrine Differentiation

The proneural transcription factor Neurogenin3 (Ngn3) plays a critical role in pancreatic endocrine cell differentiation, although regulation of Ngn3 protein is largely unexplored. Here we demonstrate that Ngn3 protein undergoes cyclin-dependent kinase (Cdk)-mediated phosphorylation on multiple seri...

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Publié dans:Dev Cell
Auteurs principaux: Azzarelli, Roberta, Hurley, Christopher, Sznurkowska, Magdalena K., Rulands, Steffen, Hardwick, Laura, Gamper, Ivonne, Ali, Fahad, McCracken, Laura, Hindley, Christopher, McDuff, Fiona, Nestorowa, Sonia, Kemp, Richard, Jones, Kenneth, Göttgens, Berthold, Huch, Meritxell, Evan, Gerard, Simons, Benjamin D., Winton, Douglas, Philpott, Anna
Format: Artigo
Langue:Inglês
Publié: Cell Press 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5425251/
https://ncbi.nlm.nih.gov/pubmed/28457793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2017.04.004
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