Multi-site Neurogenin3 Phosphorylation Controls Pancreatic Endocrine Differentiation

The proneural transcription factor Neurogenin3 (Ngn3) plays a critical role in pancreatic endocrine cell differentiation, although regulation of Ngn3 protein is largely unexplored. Here we demonstrate that Ngn3 protein undergoes cyclin-dependent kinase (Cdk)-mediated phosphorylation on multiple seri...

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Detalhes bibliográficos
Publicado no:Dev Cell
Main Authors: Azzarelli, Roberta, Hurley, Christopher, Sznurkowska, Magdalena K., Rulands, Steffen, Hardwick, Laura, Gamper, Ivonne, Ali, Fahad, McCracken, Laura, Hindley, Christopher, McDuff, Fiona, Nestorowa, Sonia, Kemp, Richard, Jones, Kenneth, Göttgens, Berthold, Huch, Meritxell, Evan, Gerard, Simons, Benjamin D., Winton, Douglas, Philpott, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5425251/
https://ncbi.nlm.nih.gov/pubmed/28457793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2017.04.004
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