Recruitment of the inhibitor Cand1 to the cullin substrate adaptor site mediates interaction to the neddylation site

Cand1 inhibits cullin RING ubiquitin ligases by binding unneddylated cullins. The Cand1 N-terminus blocks the cullin neddylation site, whereas the C-terminus inhibits cullin adaptor interaction. These Cand1 binding sites can be separated into two functional polypeptides which bind sequentially. C-te...

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Main Authors: Helmstaedt, Kerstin, Schwier, Elke U., Christmann, Martin, Nahlik, Krystyna, Westermann, Mieke, Harting, Rebekka, Grond, Stephanie, Busch, Silke, Braus, Gerhard H.
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Cell Biology 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3016973/
https://ncbi.nlm.nih.gov/pubmed/21119001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E10-08-0732
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