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Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species

Common chromosomal fragile sites FRA3B and FRA16D are frequent sites of DNA instability in cancer, but their contribution to cancer cell biology is not yet understood. Genes that span these sites (FHIT and WWOX, respectively) are often perturbed (either increased or decreased) in cancer cells and bo...

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Autors principals: O'Keefe, Louise V., Colella, Alex, Dayan, Sonia, Chen, Qingwen, Choo, Amanda, Jacob, Reuben, Price, Gareth, Venter, Deon, Richards, Robert I.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3016910/
https://ncbi.nlm.nih.gov/pubmed/21075834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq495
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