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Role of the F-box protein Skp2 in lymphomagenesis

The F-box protein Skp2 (S-phase kinase-associated protein 2) positively regulates the G(1)-S transition by controlling the stability of several G(1) regulators, such as the cell cycle inhibitor p27. We show here that Skp2 expression correlates directly with grade of malignancy and inversely with p27...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Latres, Esther, Chiarle, Roberto, Schulman, Brenda A., Pavletich, Nikola P., Pellicer, Angel, Inghirami, Giorgio, Pagano, Michele
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC30169/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11226270/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.041475098
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