Docosahexaenoic Acid-Derived Neuroprotectin D1 Induces Neuronal Survival via Secretase- and PPARγ-Mediated Mechanisms in Alzheimer's Disease Models

Neuroprotectin D1 (NPD1) is a stereoselective mediator derived from the omega-3 essential fatty acid docosahexaenoic acid (DHA) with potent inflammatory resolving and neuroprotective bioactivity. NPD1 reduces Aβ42 peptide release from aging human brain cells and is severely depleted in Alzheimer...

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Autors principals: Zhao, Yuhai, Calon, Frederic, Julien, Carl, Winkler, Jeremy W., Petasis, Nicos A., Lukiw, Walter J., Bazan, Nicolas G.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3016440/
https://ncbi.nlm.nih.gov/pubmed/21246057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0015816
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