Generating Transgenic Mice from Bacterial Artificial Chromosomes: Transgenesis Efficiency, Integration and Expression Outcomes

Transgenic mice are widely used in biomedical research to study gene expression, developmental biology, and gene therapy models. Bacterial artificial chromosome (BAC) transgenes direct gene expression at physiological levels with the same developmental timing and expression patterns as endogenous ge...

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Main Authors: Van Keuren, Margaret L., Gavrilina, Galina B., Filipiak, Wanda E., Zeidler, Michael G., Saunders, Thomas L.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3016422/
https://ncbi.nlm.nih.gov/pubmed/19396621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11248-009-9271-2
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