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Structural analysis of Pneumocystis carinii and human DHFR complexes with NADPH and a series of five potent 6-[5′-(ω-carboxyalkoxy)benzyl]pyrido[2,3-d]pyrimidine derivatives
Structural data are reported for five antifolates, namely 2,4-diamino-6-[5′-(5-carboxypentyloxy)-2′-methoxybenzyl]-5-methylpyrido[2,3-d]pyrimidine, (1), and the 5′-[3-(ethoxycarbonyl)propoxy]-, (2), 5′-[3-(ethoxycarbonyl)butoxy]-, (3), 5′-[3-(ethoxycarbonyl)pentyloxy]-, (4), and 5′-benzyloxy-, (5),...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
International Union of Crystallography
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3016015/ https://ncbi.nlm.nih.gov/pubmed/21206056 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444910041004 |
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