IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor γ1

IL-4 is a pleiotropic immune cytokine secreted by activated T(H)2 cells that inhibits bone resorption both in vitro and in vivo. The cellular targets of IL-4 action as well as its intracellular mechanism of action remain to be determined. We show here that IL-4 inhibits receptor activator of NF-κB l...

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Autors principals: Bendixen, Amy C., Shevde, Nirupama K., Dienger, Krista M., Willson, Timothy M., Funk, Colin D., Pike, J. Wesley
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2001
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC30157/
https://ncbi.nlm.nih.gov/pubmed/11226258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.041493198
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