Efficient help for autoreactive B cell activation requires CD4(+) T cell recognition of an agonist peptide at the effector stage

T cell recognition of peptide/MHC complexes is flexible and can lead to differential activation, but how interactions with agonist (full activation) or partial agonist (suboptimal activation) peptides can shape immune responses in vivo is not well characterized. We investigated the effect of stimula...

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Bibliographic Details
Main Authors: Hondowicz, Brian D., Batheja, Amrita O., Metzgar, Michele H., Pagán, Antonio J., Perng, Olivia A., Willms, Simone, Caton, Andrew J., Erikson, Jan
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3015147/
https://ncbi.nlm.nih.gov/pubmed/19662636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200939471
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