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Autoantibody production in lpr/lpr gld/gld mice reflects accumulation of CD4(+) effector cells that are resistant to regulatory T cell activity
In Fas/FasL deficient mice anti-chromatin Ab production is T cell dependent and is not apparent until after 10 weeks of age. Early control of anti-chromatin antibodies may be due to the counterbalancing influence of Treg cells. Here we show that Treg cells block lpr/lpr gld/gld Th cells from providi...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2585757/ https://ncbi.nlm.nih.gov/pubmed/18539433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2008.04.022 |
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