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Autoantibody production in lpr/lpr gld/gld mice reflects accumulation of CD4(+) effector cells that are resistant to regulatory T cell activity

In Fas/FasL deficient mice anti-chromatin Ab production is T cell dependent and is not apparent until after 10 weeks of age. Early control of anti-chromatin antibodies may be due to the counterbalancing influence of Treg cells. Here we show that Treg cells block lpr/lpr gld/gld Th cells from providi...

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Bibliografiske detaljer
Main Authors: Hondowicz, Brian D., Fields, Michele L., Nish, Simone A., Larkin, Joseph, Caton, Andrew J., Erikson, Jan
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2585757/
https://ncbi.nlm.nih.gov/pubmed/18539433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2008.04.022
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