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Interferon induces miR-21 through a STAT3-dependent pathway as a suppressive negative feedback on interferon-induced apoptosis
The microRNA miR-21 is overexpressed in many human cancers where accumulating evidence indicate it functions as an oncogene. Here we report that the cytokine; rapidly induces miR-21 expression in human and mouse cells. STAT3 was implicated in this pathway based on the lack of an effect of IFN on miR...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3014825/ https://ncbi.nlm.nih.gov/pubmed/20813833 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-2579 |
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