Post-Translational Modification and Regulation of Glutamate Cysteine Ligase by the α,β-Unsaturated Aldehyde 4-Hydroxy-2-Nonenal (4-HNE)

4-hydroxy-2-nonenal (4-HNE) is a lipid peroxidation product formed during oxidative stress that can alter protein function via adduction of nucleophilic amino acid residues. 4-HNE detoxification occurs mainly via GSH conjugation and transporter-mediated efflux. This results in a net loss of cellular...

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Main Authors: Backos, Donald S., Fritz, Kristofer S., Roede, James R., Petersen, Dennis R., Franklin, Christopher C.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014730/
https://ncbi.nlm.nih.gov/pubmed/20970495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2010.10.694
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