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Post-Translational Modification and Regulation of Glutamate Cysteine Ligase by the α,β-Unsaturated Aldehyde 4-Hydroxy-2-Nonenal (4-HNE)
4-hydroxy-2-nonenal (4-HNE) is a lipid peroxidation product formed during oxidative stress that can alter protein function via adduction of nucleophilic amino acid residues. 4-HNE detoxification occurs mainly via GSH conjugation and transporter-mediated efflux. This results in a net loss of cellular...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3014730/ https://ncbi.nlm.nih.gov/pubmed/20970495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2010.10.694 |
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