14,15-Dihydroxy-eicosa-5(Z)-enoic Acid Selectively Inhibits 14,15-Epoxyeicosatrienoic Acid-Induced Relaxations in Bovine Coronary Arteries

Cytochrome P-450 epoxygenases metabolize arachidonic acid (AA) to epoxyeicosatrienoic acids (EETs). EETs relax vascular smooth muscle by membrane hyperpolarization. 14,15-Epoxyeicosa-5(Z)-enoic acid (14,15-EE5ZE) antagonizes many vascular actions of EETs. EETs are converted to the corresponding dihy...

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Autores principales: Bukhari, Ishfaq A., Gauthier, Kathryn M., Jagadeesh, Setti G., Sangras, Bhavani, Falck, J. R., Campbell, William B.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2011
Materias:
Cardiovascular
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014297/
https://ncbi.nlm.nih.gov/pubmed/20881018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.169797
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