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20-(125)Iodo-14,15-Epoxyeicosa-5(Z)-enoic Acid: a High-Affinity Radioligand Used to Characterize the Epoxyeicosatrienoic Acid Antagonist Binding Site

Epoxyeicosatrienoic acids (EETs) are endothelium-derived metabolites of arachidonic acid. They relax vascular smooth muscle by membrane hyperpolarization. These actions are inhibited by the EET antagonist, 14,15-epoxyeicosa-5(Z)-enoic acid (14,15-EE5ZE). We synthesized 20-(125)iodo-14,15-EE5ZE (20-(...

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Bibliografiset tiedot
Päätekijät: Chen, Yuenmu, Falck, John R., Tuniki, Venugopal R., Campbell, William B.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The American Society for Pharmacology and Experimental Therapeutics 2009
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784706/
https://ncbi.nlm.nih.gov/pubmed/19762546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.109.157818
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