Identification of 13-Hydroxy-14,15-epoxyeicosatrienoic Acid as an Acid-stable Endothelium-derived Hyperpolarizing Factor in Rabbit Arteries

Arachidonic acid (AA) is metabolized by endothelial 15-lipoxygenase (15-LO) to several vasodilatory eicosanoids such as 11,12,15-trihydroxyeicosatrienoic acid (11,12,15-THETA) and its proposed unstable precursor 15-hydroxy-11,12-epoxyeicosatrienoic acid (15-H-11,12-EETA). In the present study, the a...

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Main Authors: Chawengsub, Yuttana, Gauthier, Kathryn M., Nithipatikom, Kasem, Hammock, Bruce D., Falck, John R., Narsimhaswamy, Dubasi, Campbell, William B.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781526/
https://ncbi.nlm.nih.gov/pubmed/19737933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.025627
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