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CGP-37157 Inhibits the Sarcoplasmic Reticulum Ca(2+) ATPase and Activates Ryanodine Receptor Channels in Striated Muscle
7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one [CGP-37157 (CGP)], a benzothiazepine derivative of clonazepam, is commonly used as a blocker of the mitochondrial Na(+)/Ca(2+) exchanger. However, evidence suggests that CGP could also affect other targets, such as L-type Ca(2+) ch...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3014283/ https://ncbi.nlm.nih.gov/pubmed/20923851 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.067165 |
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