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Identification of Clinically Used Drugs That Activate Pregnane X Receptors
The pregnane X receptor (PXR) binds xenobiotics and regulates the expression of several drug-metabolizing enzymes and transporters. Human PXR (hPXR) activation and CYP3A4 induction can be involved in drug-drug interactions, resulting in reduced efficacy or increased toxicity. However, there are know...
Gorde:
| Egile Nagusiak: | , , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
The American Society for Pharmacology and Experimental
Therapeutics
2011
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3014269/ https://ncbi.nlm.nih.gov/pubmed/20966043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.110.035105 |
| Etiketak: |
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