Identification of Clinically Used Drugs That Activate Pregnane X Receptors

The pregnane X receptor (PXR) binds xenobiotics and regulates the expression of several drug-metabolizing enzymes and transporters. Human PXR (hPXR) activation and CYP3A4 induction can be involved in drug-drug interactions, resulting in reduced efficacy or increased toxicity. However, there are know...

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Main Authors: Shukla, Sunita J., Sakamuru, Srilatha, Huang, Ruili, Moeller, Timothy A., Shinn, Paul, VanLeer, Danielle, Auld, Douglas S., Austin, Christopher P., Xia, Menghang
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014269/
https://ncbi.nlm.nih.gov/pubmed/20966043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.110.035105
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