Bone homeostasis in growth hormone receptor–null mice is restored by IGF-I but independent of Stat5

Growth hormone (GH) regulates both bone growth and remodeling, but it is unclear whether these actions are mediated directly by the GH receptor (GHR) and/or IGF-I signaling. The actions of GH are transduced by the Jak/Stat signaling pathway via Stat5, which is thought to regulate IGF-I expression. T...

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Main Authors: Sims, Natalie A., Clément-Lacroix, Philippe, Da Ponte, Francesca, Bouali, Yasmina, Binart, Nadine, Moriggl, Richard, Goffin, Vincent, Coschigano, Karen, Gaillard-Kelly, Martine, Kopchick, John, Baron, Roland, Kelly, Paul A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2000
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC301420/
https://ncbi.nlm.nih.gov/pubmed/11067862
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