STAT5 Is an Ambivalent Regulator of Neutrophil Homeostasis

BACKGROUND: Although STAT5 promotes survival of hematopoietic progenitors, STAT5(−/−) mice develop mild neutrophilia. METHODOLOGY/PRINCIPAL FINDINGS: Here, we show that in STAT5(−/−) mice, liver endothelial cells (LECs) autonomously secrete high amounts of G-CSF, allowing myeloid progenitors to over...

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Detalhes bibliográficos
Main Authors: Fiévez, Laurence, Desmet, Christophe, Henry, Emmanuelle, Pajak, Bernard, Hegenbarth, Silke, Garzé, Virginie, Bex, Françoise, Jaspar, Fabrice, Boutet, Philippe, Gillet, Laurent, Vanderplasschen, Alain, Knolle, Percy A., Leo, Oberdan, Moser, Muriel, Lekeux, Pierre, Bureau, Fabrice
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1939728/
https://ncbi.nlm.nih.gov/pubmed/17710127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0000727
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