Varicella-Zoster Virus Glycoprotein E Is a Critical Determinant of Virulence in the SCID Mouse-Human Model of Neuropathogenesis

Varicella-zoster virus (VZV) is a neurotropic alphaherpesvirus. VZV infection of human dorsal root ganglion (DRG) xenografts in immunodeficient mice models the infection of sensory ganglia. We examined DRG infection with recombinant VZV (recombinant Oka [rOka]) and the following gE mutants: gEΔ27-90...

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Bibliographische Detailangaben
Hauptverfasser: Zerboni, Leigh, Berarducci, Barbara, Rajamani, Jaya, Jones, Carol D., Zehnder, James L., Arvin, Ann
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2011
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014186/
https://ncbi.nlm.nih.gov/pubmed/20962081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01902-10
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